Sodium hydride → 1-(2-phthalimidoethyl)-5,7-dimethyl-1,8-naphthyridin-2(1H)-one

HRID 903876

反応式

HRID 903876 の反応式
[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[N:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](=[O:13])[NH:7]2.[H-].[Na+].Cl[CH2:17][CH2:18][N:19]1[C:23](=[O:24])[C:22]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:21]2[C:20]1=[O:29]>CN(C)C=O>[C:20]1(=[O:29])[N:19]([CH2:18][CH2:17][N:7]2[C:8]3[C:3](=[C:2]([CH3:1])[CH:11]=[C:10]([CH3:12])[N:9]=3)[CH:4]=[CH:5][C:6]2=[O:13])[C:23](=[O:24])[C:22]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:21]12

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 234274N-(2-Chloroethyl)phthalimideHCID 53744055,7-dimethyl-1,8-naphthyridin-2(1H)-one

生成物 1

HCID 233354051-(2-phthalimidoethyl)-5,7-dimethyl-1,8-naphthyridin-2(1H)-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

To a suspension of 5,7-dimethyl-1,8-naphthyridin-2(1H)-one (3.5 g., 0.02 mole) in 25 ml. of dry dimethyl formamide under nitrogen atmosphere is added a 57% suspension of sodium hydride in mineral oil (0.84 g., 0.02 mole). This mixture is stirred at room temperature for 1/2 hour. A mixture of N-(2-chloroethyl) phthalimide (4.6 g., 0.022 mole) in 25 ml. of dry dimethylformamide is added to the first suspension. The mixture is stirred at steam bath temperature for 16 hours. On cooling, it is filtered to remove salt and the filtrate evaporated to dryness in vacuo to afford 1-(2-phthalimidoethyl)-5,7-dimethyl-1,8-naphthyridin-2(1H)-one.

後処理

  1. stirringThe mixture is stirred at steam bath temperature for 16 hours
  2. temperatureOn cooling
  3. filtrationit is filtered
  4. customto remove salt
  5. customthe filtrate evaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-59ca0f7c59a542658e4977b661a6f56f
出典データセット
uspto-grants-1980_10
特許番号
US04229456

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