Ethyl 4-(benzyloxy)-6-methyl-1H-indole-2-carboxylate → 4-Hydroxy-2-ethoxycarbonyl-6-methylindole

HRID 903919ノート

反応式

HRID 903919 の反応式
C([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[NH:13]2)C1C=CC=CC=1>CO.C(O)C.[Pd]>[OH:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[NH:13]2

参加物

5

反応物 1

HCID 23335518Ethyl 4-(benzyloxy)-6-methyl-1H-indole-2-carboxylate

生成物 1

HCID 233354994-Hydroxy-2-ethoxycarbonyl-6-methylindole

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

11.0 g of the thus obtained 4-benzyloxy-2-ethoxycarbonyl-6-methyl indole are suspended in 150 ml methanol and, after addition of a suspension of 1.0 g, 10% Pd/C in 20 ml ethanol hydrogenated at normal pressure in a duck-shaped shaking vessel. The catalyst is aspirated and the filtrate is evaporated. There is obtained pure 4-hydroxy-2-ethoxycarbonyl-6-methylindole in virtually quantitative yield.

後処理

  1. customhydrogenated at normal pressure in a duck-shaped shaking vessel
  2. customthe filtrate is evaporated

出典と根拠

ORDレコード
ord-1f6cfef92aec45a8b98b7bcba030bc8f
出典データセット
uspto-grants-1980_10
特許番号
US04229464

反応ノート

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