Dimethyl ether ethylene glycol → 4-Hydroxy-2-carbamoyl-6-methyl indole
反応式
C([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19](=[O:21])[NH2:20])[NH:13]2)C1C=CC=CC=1.C(O)CO.COC.[H][H]>[Pd].CO>[OH:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19](=[O:21])[NH2:20])[NH:13]2参加物
6
実験手順
8.5 g of the thus obtained 4-benzyloxy-2-carbamoyl-6-methyl indole are hydrogenated in a composition of 100 ml methanol and 50 ml ethylene glycol-dimethyl ether during addition of 1.0 g 10% Pd/C up to the absorption of the theoretical amount of hydrogen. The catalyst is aspirated and the filtrate is evaporated in vacuum. There is obtained 5.4 (~93% of theory) 4-hydroxy-2-carbamoyl-6-methyl indole as a light yellow syrup.
後処理
- customthe filtrate is evaporated in vacuum
出典と根拠
- ORDレコード
- ord-d99d1b05acac4a8d8cbd0664b21e16b1
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04229464
反応ノート
読み込み中…