3,5-Dichlorobenzoic acid → 3,5-Dichlorobenzoyl chloride

HRID 904095

反応式

HRID 904095 の反応式
[Cl:1]C1C=C(C=C(Cl)C=1)C(C)=C.S(Cl)(Cl)=O.[Cl:16][C:17]1[CH:18]=[C:19]([CH:23]=[C:24]([Cl:26])[CH:25]=1)[C:20](O)=[O:21]>>[Cl:16][C:17]1[CH:18]=[C:19]([CH:23]=[C:24]([Cl:26])[CH:25]=1)[C:20]([Cl:1])=[O:21]

参加物

4

反応物 3

HCID 58113,5-Dichlorobenzoic acidHCID 24386Thionyl ChlorideHCID 1106043,5-Dichloro-alpha-methylstyrene

生成物 1

HCID 761913,5-Dichlorobenzoyl chloride

実験手順

It has been known that 3,5-dichloro-α-methylstyrene can be produced by reacting thionyl chloride with 3,5-dichlorobenzoic acid to obtain 3,5-dichlorobenzoyl chloride and then reacting methanol with 3,5-dichlorobenzoyl chloride to obtain methyl-3,5-dichlorobenzoate and reacting methylmagnesium chloride with methyl-3,5-dichlorobenzoate in ether and then, hydrolyzing the product with a diluted hydrochloric acid and dehydrating the product over sodium bisulfate, in for example, Journal of the American Chemical Society 73 January 1951, page 455-456. However, this process is not advantageous as an industrial process because many reaction steps are needed for producing methyl3,5-dichlorobenzoate and a complicated reaction step is included in these steps for producing the starting material and the hydrolysis and the dehydration should be separately carried out.

後処理

  1. customcan be produced

出典と根拠

ORDレコード
ord-4c21f5935dea4e088905616f3b1cbb8d
出典データセット
uspto-grants-1980_10
特許番号
US04230642

関連ノート

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