Ethanol → (2,4-Dimethylthiophen-3-yl)methanol

HRID 904472ノート

反応式

HRID 904472 の反応式
[BH4-].[Na+].[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH:9]=[O:10].C(O)C>O>[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH2:9][OH:10]

参加物

5

反応物 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 111477702,4-Dimethylthiophene-3-carbaldehyde

生成物 1

HCID 12875266(2,4-Dimethylthiophen-3-yl)methanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.68 G. (18 mmol) of sodium borohydride was added in three portions to a solution of 10.08 g. (72 mmol) of 2,4-dimethylthiophene-3-carboxaldehyde in 120 ml. of ethanol. After 15 min., the reaction mixture was poured into water, extracted with ether, dried and the solvent evaporated. The resulting residue was recrystallized from hexane to yield 2,4-dimethyl-3-hydroxymethylthiophene, m.p. 80°-81° C.

後処理

  1. extractionextracted with ether
  2. customdried
  3. customthe solvent evaporated
  4. customThe resulting residue was recrystallized from hexane

出典と根拠

ORDレコード
ord-b7d87ca55c9d4cf4a21bc8b6ee985286
出典データセット
uspto-grants-1980_10
特許番号
US04230872

反応ノート

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