Sodium borohydride → HCID 12875271、化合物
反応式
[Br:1][C:2]1[C:3]([CH3:10])=[C:4]([CH:8]=[O:9])[S:5][C:6]=1[CH3:7].[BH4-].[Na+]>C(O)C>[Br:1][C:2]1[C:3]([CH3:10])=[C:4]([CH2:8][OH:9])[S:5][C:6]=1[CH3:7]参加物
4
実験手順
11.8 G. of 4-bromo-3,5-dimethylthiophene-2-carboxaldehyde was dissolved in 250 ml. of dry ethanol and stirred at 20° C. 0.52 G. of sodium borohydride was added and the resulting solution was stirred for 30 minutes, then poured into ice water and extracted with ethyl ether. The combined ether extracts were washed with a solution of 5% sodium carbonate and a saturated sodium chloride solution, dried over sodium sulfate, filtered and evaporated. Crystallization from cold hexane yielded 4-bromo-3,5-dimethyl-2-hydroxymethylthiophene, m.p. 85°-90° C.
後処理
- extractionextracted with ethyl ether
- washThe combined ether extracts were washed with a solution of 5% sodium carbonate
- dry with materiala saturated sodium chloride solution, dried over sodium sulfate
- filtrationfiltered
- customevaporated
- customCrystallization from cold hexane
出典と根拠
- ORDレコード
- ord-edeb140429b74409906c9ba182cb3789
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04230872
反応ノート
読み込み中…