Hydrochloric Acid → N-[4-(cyanoacetyl)phenyl]propane-1-sulfonamide

HRID 904881

反応式

HRID 904881 の反応式
[CH2:1]([S:4](Cl)(=[O:6])=[O:5])[CH2:2][CH3:3].C(OC)(=O)C.[NH2:13][C:14]1[CH:24]=[CH:23][C:17]([C:18]([CH2:20][C:21]#[N:22])=[O:19])=[CH:16][CH:15]=1.Cl>CO.N1C=CC=CC=1>[CH2:1]([S:4]([NH:13][C:14]1[CH:15]=[CH:16][C:17]([C:18]([CH2:20][C:21]#[N:22])=[O:19])=[CH:23][CH:24]=1)(=[O:6])=[O:5])[CH2:2][CH3:3]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 6584Methyl AcetateHCID 662791-Propanesulfonyl chlorideHCID 96920Benzenepropanenitrile, 4-amino-beta-oxo-

生成物 1

HCID 19737109N-[4-(cyanoacetyl)phenyl]propane-1-sulfonamide

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 1049Pyridine溶媒

実験手順

Dry pyridine (13 ml) was added dropwise to a stirred mixture of 14.3 g (0.1 mole) 1-propanesulfonyl chloride, 15 ml dry methyl acetate and 16.0 g (0.1 mole) 4-aminobenzoylacetonitrile at room temperature. An ice bath was then used to control the exothermic reaction and the mixture was stirred in the ice bath for two hours. Methanol (50 ml) was added and the resulting solution poured into 2 N hydrochloric acid (240 ml) with stirring. The solid was collected, washed with water and dried. Yield 20.7 g (78%). Recrystallization yielded product melting at 150°-151° C.

後処理

  1. customAn ice bath was then used
  2. customthe exothermic reaction
  3. customThe solid was collected
  4. washwashed with water
  5. customdried
  6. customRecrystallization

出典と根拠

ORDレコード
ord-b4f528ab21f442ddbee4020299ea6d00
出典データセット
uspto-grants-1983_12
特許番号
US04420555

関連ノート

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