HCID 13277357、化合物 → HCID 13277360、化合物
反応式
[CH3:1][N:2]([CH3:18])[CH2:3][CH2:4][N:5]1[C:10]2[N:11]=[C:12]([CH3:16])[CH:13]=[C:14]([CH3:15])[C:9]=2[CH2:8][NH:7][C:6]1=[O:17]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:18][N:2]([CH3:1])[CH2:3][CH2:4][N:5]1[C:10]2[N:11]=[C:12]([CH3:16])[CH:13]=[C:14]([CH3:15])[C:9]=2[CH:8]=[N:7][C:6]1=[O:17]参加物
4
実験手順
A solution of 1-(2-dimethylaminoethyl)-5,7-dimethyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-2-one (5.0 g, 20 mmol) in chloroform (150 ml) containing activated manganese dioxide (15 g) is refluxed for 15 hours. The reaction mixture is filtered hot and the collected manganese dioxide re-extracted with hot chloroform. The combined organic extracts are evaporated and the residue crystallized from cyclohexane to yield 2.4 g of pure title product; m.p.: 137°-139° C.