Potassium Carbonate → HCID 13101188、化合物

HRID 905202ノート

反応式

HRID 905202 の反応式
[CH2:1]([NH:3][C:4](F)=[O:5])[CH3:2].[C:7]([N:11]1[CH:15]=[C:14]([OH:16])[CH:13]=[N:12]1)([CH3:10])([CH3:9])[CH3:8].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:1]([NH:3][C:4](=[O:5])[O:16][C:14]1[CH:13]=[N:12][N:11]([C:7]([CH3:10])([CH3:9])[CH3:8])[CH:15]=1)[CH3:2]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 130714731-tert-Butyl-1H-pyrazol-4-olHCID 20475966HCID 20475966、化合物

生成物 1

HCID 13101188HCID 13101188、化合物収率 85.2%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
20 °C

実験手順

4.6 g (0.05 mol) of N-ethylcarbamoyl fluoride were added to a mixture of 7 g (0.05 mol) of 1-tert.-butyl-4-hydroxypyrazole, 10.4 g (0.075 mol) of potassium carbonate and 100 ml of acetonitrile. The mixture was stirred for a further 3 hours at 20° C. It was then filtered under suction. The filtrate was concentrated by evaporation in vacuo. 9 g (85% of theory) of 1-tert.-butyl-pyrazol-4-yl N-ethylcarbamate were obtained in the form of beige crystals with a melting point of 77° C.

後処理

  1. filtrationIt was then filtered under suction
  2. concentrationThe filtrate was concentrated by evaporation in vacuo

出典と根拠

ORDレコード
ord-28a08fb5388446d5991f06eab1b62a02
出典データセット
uspto-grants-1983_12
特許番号
US04423058

反応ノート

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