Triethylamine → Methanesulphonylpyrazoline

HRID 905324

反応式

HRID 905324 の反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH:6]1[CH2:10][CH:9]=[CH:8][NH:7]1.C(N(CC)CC)C>C(Cl)Cl>[CH3:1][S:2]([N:7]1[CH2:8][CH:9]=[CH:10][NH:6]1)(=[O:4])=[O:3]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 41560032,3-dihydro-1H-pyrazole

生成物 1

HCID 54062380Methanesulphonylpyrazoline収率 77%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

114.5 g of methanesulphonic acid chloride were added dropwise to 70 g of pyrazoline and 101 g of triethylamine in 300 ml of methylene chloride at room temperature. The mixture was subsequently stirred at room temperature for 3 hours and was filtered. The filtrate was washed with water, dried over sodium sulphate and concentrated. 114 g (77% of theory) of methanesulphonylpyrazoline of melting point 62° C. were obtained.

後処理

  1. filtrationwas filtered
  2. washThe filtrate was washed with water
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-a07ead0b1aaa4c1bb2f33c4ae7d2feac
出典データセット
uspto-grants-1983_12
特許番号
US04423225

関連ノート

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