Cyclopentylacetyl chloride → 2-Cyclopentyl-N-(2,6-difluoro-4-morpholin-4-yl-phenyl)-acetamide

HRID 905591

反応式

HRID 905591 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:5]=[C:4]([F:14])[C:3]=1[NH2:15].[CH:16]1([CH2:21][C:22](Cl)=[O:23])[CH2:20][CH2:19][CH2:18][CH2:17]1>C(#N)C>[CH:16]1([CH2:21][C:22]([NH:15][C:3]2[C:2]([F:1])=[CH:7][C:6]([N:8]3[CH2:9][CH2:10][O:11][CH2:12][CH2:13]3)=[CH:5][C:4]=2[F:14])=[O:23])[CH2:20][CH2:19][CH2:18][CH2:17]1

参加物

4

反応物 2

HCID 3485182Cyclopentylacetyl chlorideHCID 592443842,6-Difluoro-4-morpholin-4-yl-phenylamine

生成物 1

HCID 116022552-Cyclopentyl-N-(2,6-difluoro-4-morpholin-4-yl-phenyl)-acetamide収率 75%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
150 °C

実験手順

2,6-Difluoro-4-morpholin-4-yl-phenylamine (0.20 g) and cyclopentylacetyl chloride (149 μL) were dissolved in acetonitrile (4 mL) and heated to 150° C. for 10 minutes in a sealed microwave process vial. The reaction mixture was concentrated in vacuo and purified by flash chromatography to furnish 228 mg (75%) of the title compound as a white solid.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by flash chromatography

出典と根拠

ORDレコード
ord-d85462fd6d864d39a916dd2b5d889390
出典データセット
uspto-grants-2011_09
特許番号
US08012962B2

関連ノート

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