N-(2-(2-((3-fluorophenyl)imino)-4-(4-morpholin-4-ylphenyl)-1,3-thiazol-3(2H)-yl)ethyl)-N'-methylurea → HCID 67404113、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]2[N:13]([CH2:14][CH2:15][NH:16][C:17]([NH:19][CH3:20])=[O:18])[C:12]([C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)=[CH:23][CH:22]=3)=[CH:11][S:10]2)[CH:5]=[CH:6][CH:7]=1.[BrH:33].CC(O)=O>C(Cl)(Cl)Cl>[BrH:33].[F:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]2[N:13]([CH2:14][CH2:15][NH:16][C:17]([NH:19][CH3:20])=[O:18])[C:12]([C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)=[CH:23][CH:22]=3)=[CH:11][S:10]2)[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
To a suspension of N-{2-[2-[(3-fluorophenyl)imino]-4-(4-morpholin-4-ylphenyl)-1,3-thiazol-3(2H)-yl]ethyl}-N′-methylurea (455 mg) in chloroform (50 ml) was added 25% HBr/AcOH (0.32 g), and the mixture was stirred to dissolve for 30 minutes. The solvent was removed, and then thereto was added diethylether and a precipitate was filtered to give crystals (520 mg) of which a melting point was 191 to 193° C.