C(O[C:5](=[O:7])C)(=O)C.C(O)=O.N[C:12]1[CH:20]=[C:19]2[C:15]([C:16](=CC3NC4CCN(CCN(CC)CC)C(=O)C=4C=3C)[C:17](=[O:21])[NH:18]2)=[CH:14][C:13]=1[F:41].[NH:42]1CCCCC1>O1CCCC1>[F:41][C:13]1[CH:14]=[C:15]2[C:19](=[C:20]([NH:42][CH:5]=[O:7])[CH:12]=1)[NH:18][C:17](=[O:21])[CH2:16]2A solution of acetic anhydride (1.6 ml) and formic acid (1.2 ml) was stirred for 1 hour at room temperature, and added with 6-amino-5-fluoro-1,3-dihydro-indol-2-one (4.0 g, 24 mmol) obtained from Example 7 in 60 ml of tetrahydrofuran and piperidine (0.04 ml). Upon the completion of the addition, the mixture was stirred for 3 hours at room temperature until a precipitate was formed. The solid was filtered and recrystallized from methanol to give N-(5-fluoro-2-oxo-2,3-dihydro-1H-indol-7-yl)-formamide (4.6 g, 99%) as a white solid.
読み込み中…
