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Phenethyl isocyanate → 1-phenethyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenethyl isocyanate | HCID 160602 | — |
| 反応物 | 5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamine | HCID 59363369 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-phenethyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea | HCID 59363365 | 55% |
反応手順
A solution of 5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamine (0.260 g, 0.98 mmol) in 15 mL of dichloromethane was cooled to −30° C. Phenethyl isocyanate (0.21 g, 1.5 mmol) was added, and the resulting solution was stirred at room temperature for 14 h, then concentrated to a residue. Column chromatography afforded 0.220 g (55%) of 1-phenethyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08012974B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-5546393eb1494906841a9b27754965fc |
| 出典メモ | uspto-grants-2011_09 |