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(R)-sec-butylamine → 4-(aminocarbonyl)-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (R)-sec-butylamine | HCID 2724537 | — |
| 反応物 | ethyl 2-bromo-4-cyano-5-{[(1R)-1-methylpropyl]amino}benzoate | HCID 67404527 | — |
| 反応物 | ethyl 4-cyano-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoate | HCID 67405722 | — |
| 生成物 | 4-(aminocarbonyl)-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoic acid | HCID 57748590 | — |
反応手順
Synthesized according to the method of reagent preparation 50 by using (1R)-1-methylpropylamine in step 1 then following step 2 with the conversion of ethyl 2-bromo-4-cyano-5-{[(1R)-1-methylpropyl]amino}benzoate to ethyl 4-cyano-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoate according to the method described in step 1 then proceeding through steps 3 and 4. MS (EI) for C14H21N3O3: 280 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08012956B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-445f68c7ef214569aad75372bc727aca |
| 出典メモ | uspto-grants-2011_09 |