反応式
[OH:1][C@H:2]1[CH2:6][NH:5][C@@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1.S(Cl)(Cl)=O.[CH2:14](O)[CH3:15]>>[CH2:14]([O:8][C:7]([C@H:4]1[CH2:3][C@@H:2]([OH:1])[CH2:6][NH:5]1)=[O:9])[CH3:15]参加物
4
実験手順
To a stirred solution of cis-4-hydroxy-pyrrolidine-2-carboxylic acid (1 g, 7.6 mmol) in absolute ethanol (20 mL) is added dropwise thionyl chloride (0.67 mL, 9.15 mmol) at 0° C. under nitrogen atmosphere. The reaction mixture is then refluxed under nitrogen for about 2 h. The mixture is cooled to room temperature, and all solvent is removed under reduced pressure. The white precipitate is filtered and washed with diethyl ether (1×25 mL), to obtain compound (1) as a white solid.
後処理
- temperatureThe reaction mixture is then refluxed under nitrogen for about 2 h
- customall solvent is removed under reduced pressure
- filtrationThe white precipitate is filtered
- washwashed with diethyl ether (1×25 mL)
出典と根拠
- ORDレコード
- ord-98e4c14cff344515843593c5d1a72215
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08012983B2
関連ノート
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