Methyl iodide → 5,5-Dimethyl-2-methylsulphanyl-3,4,5,6-tetrahydropyrimidinium hydroiodide

HRID 906226ノート

反応式

HRID 906226 の反応式
[CH3:1][C:2]1([CH3:9])[CH2:7][NH:6][C:5](=[S:8])[NH:4][CH2:3]1.[I:10][CH3:11]>CO>[IH:10].[CH3:1][C:2]1([CH3:9])[CH2:7][NH+:6]=[C:5]([S:8][CH3:11])[NH:4][CH2:3]1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 38664875,5-Dimethyl-1,4,5,6-tetrahydro-pyrimidine-2-thiol

生成物 1

HCID 866001675,5-Dimethyl-2-methylsulphanyl-3,4,5,6-tetrahydropyrimidinium hydroiodide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The reaction mixture comprising one equivalent of 5,5-dimethyl-3,4,5,6-tetrahydro(1H)pyrimidine-2-thione and 1.2 equivalents of iodomethane in methanol (10 ml/g of thio-urea) is heated under reflux for 5 hours. After cooling down, the methanol is evaporated off under reduced pressure in order to quantitatively produce the product. The precipitate can then be washed in acetone or petroleum ether.

後処理

  1. temperatureunder reflux for 5 hours
  2. temperatureAfter cooling down
  3. customthe methanol is evaporated off under reduced pressure in order
  4. customto quantitatively produce the product
  5. washThe precipitate can then be washed in acetone

出典と根拠

ORDレコード
ord-74e08c4ab9b149f9950b4f135f462d6e
出典データセット
uspto-grants-2011_09
特許番号
US08012985B2

反応ノート

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