Chlorosulfonic acid → 6-Bromo-1-oxo-1,2-dihydroisoquinoline-4-sulfonyl chloride

反応式

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]2.[S:13]([Cl:17])(=O)(=[O:15])[OH:14]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[S:13]([Cl:17])(=[O:15])=[O:14]

参加物

反応物 2

HCID 24638Chlorosulfonic acid2 回

HCID 158851826-Bromoisoquinolin-1(2H)-one

生成物 1

HCID 574399006-Bromo-1-oxo-1,2-dihydroisoquinoline-4-sulfonyl chloride

実験手順

A solution of 6-bromoisoquinolin-1(2H)-one (10 g) in chlorosulfuric acid (29.9 mL) was heated at 90° C. for 2 h. Chlorosulfuric acid (29.9 mL) was added, and the reaction mixture was poured onto ice (CAUTION). The resulting solid was filtered, washed with water, and dried in vacuo (25° C.) to give the subtitle compound as a beige solid (12.31 g).

後処理

additionthe reaction mixture was poured onto ice (CAUTION)
filtrationThe resulting solid was filtered
washwashed with water
customdried in vacuo (25° C.)

出典と根拠

ORDレコード: ord-49012547d6a24f8a86b84632c82935d7
出典データセット: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08012980B2

反応ノート

読み込み中…

参加物