Hydrochloric Acid → HCID 57439914、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[S:13](Cl)(=O)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O.Cl>C1COCC1.C(OCC)(=O)C.CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[SH:13]参加物
8
実験手順
To a solution of 6-bromo-1-oxo-1,2-dihydroisoquinoline-4-sulfonyl chloride (Example 46a, 1 g) in THF (12 mL) was added triphenylphosphine (2.85 g). After 5 min, water (0.48 mL) was added followed by DMF (0.6 mL) and the reaction stirred for 1 h. Ethyl acetate and 2M HCl (aq) were added and the mixture shaken vigorously. The solid was filtered off and washed with further water and ethyl acetate before drying in vacuo at room temperature is for 2 h to afford the subtitle compound (0.2 g).
後処理
- stirringthe mixture shaken vigorously
- filtrationThe solid was filtered off
- washwashed with further water and ethyl acetate
- custombefore drying in vacuo at room temperature
- waitis for 2 h
出典と根拠
- ORDレコード
- ord-fd6392823a4747a2bef17464c98e432a
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08012980B2
反応ノート
読み込み中…
