Hydrochloric Acid → Ethyl 2-(3,5-difluorophenyl)-3-hydroxy-2-propenoate

HRID 906486ノート

反応式

HRID 906486 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[H-].[Na+].Cl.[CH:18](OCC)=[O:19]>>[F:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:18][OH:19])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 11481060Ethyl 2-(3,5-difluorophenyl)acetate

生成物 1

HCID 67388060Ethyl 2-(3,5-difluorophenyl)-3-hydroxy-2-propenoate

実験手順

5.0 g of ethyl 3,5-difluorophenylacetate are dissolved in 50 ml of ethyl formate. 2.0 g of 60% NaH are added portionwise. The mixture is poured onto a 1N HCl solution and then extraction is carried out with AcOEt. The residue is triturated in petroleum ether, the remaining white precipitate is filtered off and then the filtrate is evaporated to produce 3.3 g of the expected compound in the form of a liquid.

後処理

  1. extractionextraction
  2. customThe residue is triturated in petroleum ether
  3. filtrationthe remaining white precipitate is filtered off
  4. customthe filtrate is evaporated

出典と根拠

ORDレコード
ord-7aea890950ef439393eeb37a0b9fc503
出典データセット
uspto-grants-2011_09
特許番号
US08012991B2

反応ノート

読み込み中…