benzyl (2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidine-1-carboxylate → (2S,3S)-3-ethyl-2-methylpyrrolidin-3-ol

HRID 906950ノート

反応式

HRID 906950 の反応式
[CH2:1]([C@:3]1([OH:19])[CH2:7][CH2:6][N:5](C(OCC2C=CC=CC=2)=O)[C@H:4]1[CH3:18])[CH3:2]>[Pd].O>[CH2:1]([C@:3]1([OH:19])[CH2:7][CH2:6][NH:5][C@H:4]1[CH3:18])[CH3:2]

参加物

4

反応物 1

HCID 59273017benzyl (2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidine-1-carboxylate

生成物 1

HCID 59273028(2S,3S)-3-ethyl-2-methylpyrrolidin-3-ol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidine-1-carboxylate (1.95 g) and 50% water containing-10% Pd/C (0.05 g), the title compound was obtained as a colorless solid (yield: 1.20 g, yield: 93%).

出典と根拠

ORDレコード
ord-e78bf1ed937c4dab9faf54783d1938cd
出典データセット
uspto-grants-2011_09
特許番号
US08013008B2

反応ノート

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