benzyl (2S,3S)-3-hydroxy-2-methyl-3-(trifluoromethyl)pyrrolidine-1-carboxylate → (2S,3S)-2-methyl-3-(trifluoromethyl)pyrrolidin-3-ol

HRID 906954ノート

反応式

HRID 906954 の反応式
[OH:1][C@@:2]1([C:18]([F:21])([F:20])[F:19])[CH2:6][CH2:5][N:4](C(OCC2C=CC=CC=2)=O)[C@H:3]1[CH3:17]>[Pd].O>[CH3:17][C@H:3]1[C@@:2]([C:18]([F:20])([F:19])[F:21])([OH:1])[CH2:6][CH2:5][NH:4]1

参加物

4

反応物 1

HCID 59273049benzyl (2S,3S)-3-hydroxy-2-methyl-3-(trifluoromethyl)pyrrolidine-1-carboxylate

生成物 1

HCID 59273044(2S,3S)-2-methyl-3-(trifluoromethyl)pyrrolidin-3-ol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-3-hydroxy-2-methyl-3-(trifluoromethyl)pyrrolidine-1-carboxylate (1.05 g) and 50% water containing-10% Pd/C (0.05 g), the title compound was obtained as a colorless solid (yield: 0.65 g, yield: 88%).

出典と根拠

ORDレコード
ord-9b20bdabfe60473183b437d76f1b2928
出典データセット
uspto-grants-2011_09
特許番号
US08013008B2

反応ノート

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