Dimethylamine → [(5-Chloro-1H-indol-3-yl)-p-tolyl-methyl]-dimethyl-amine

反応式

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[Cl-].[CH3:12][C:13]1[CH:22]=[CH:21][C:16]([CH:17]=[N+:18]([CH3:20])[CH3:19])=[CH:15][CH:14]=1.CC1C=CC(C=O)=CC=1.CNC>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:17]([N:18]([CH3:19])[CH3:20])[C:16]1[CH:21]=[CH:22][C:13]([CH3:12])=[CH:14][CH:15]=1

参加物

反応物 4

HCID 674Dimethylamine

HCID 77254-Methylbenzaldehyde

HCID 871105-Chloroindole

HCID 13930190N,N-Dimethyl(4-methylphenyl)methaniminium chloride

生成物 1

HCID 21985334[(5-Chloro-1H-indol-3-yl)-p-tolyl-methyl]-dimethyl-amine

実験手順

The preparation was carried out in accordance with general synthesis instructions 4 from 5-chloro-1H-indole and (4-methyl-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 4-methyl-benzaldehyde and dimethylamine.