[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][OH:6].CC(C)([O-])C.[K+].Br[C:15]1[N:20]=[CH:19][C:18]([CH2:21][N:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[C:27]([C:32]4[CH:33]=[C:34]([CH:41]=[CH:42][C:43]=4[CH3:44])[C:35]([NH:37][CH:38]4[CH2:40][CH2:39]4)=[O:36])[CH:28]=3)[C:23]2=[O:45])=[CH:17][CH:16]=1>C1COCC1>[CH:38]1([NH:37][C:35](=[O:36])[C:34]2[CH:41]=[CH:42][C:43]([CH3:44])=[C:32]([C:27]3[CH:28]=[C:29]4[C:24](=[CH:25][CH:26]=3)[C:23](=[O:45])[N:22]([CH2:21][C:18]3[CH:19]=[N:20][C:15]([O:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:7])[CH3:1])=[CH:16][CH:17]=3)[CH:31]=[CH:30]4)[CH:33]=2)[CH2:39][CH2:40]1To solution of 3-(dimethylamino)propan-1-ol (0.03 mL) in THF (1 mL) was added potassium tert-butoxide (28 mg) and the reaction stirred at room temperature for 10 minutes. A solution of the product of step i) (100 mg) in THF (2 mL) was added, and the mixture heated at reflux for 100 hours.
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