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Ammonia → 6-(5-Cyclopropylcarbamoyl-2-methyl-phenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydro-isoquinoline-4-carboxylic acid piperidin-4-ylamide

HRID 907285
ノート
印刷プレビュー

反応式

HRID 907285 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([C:27]4[CH:32]=[C:31]([C:33](=[O:38])[NH:34][CH:35]5[CH2:37][CH2:36]5)[CH:30]=[CH:29][C:28]=4[CH3:39])[CH:25]=3)[C:20](=[O:40])[N:19]([CH2:41][C:42]3[CH:47]=[CH:46][N:45]=[CH:44][CH:43]=3)[CH:18]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O.N>ClCCl>[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([C:27]4[CH:32]=[C:31]([C:33](=[O:38])[NH:34][CH:35]5[CH2:36][CH2:37]5)[CH:30]=[CH:29][C:28]=4[CH3:39])[CH:25]=3)[C:20](=[O:40])[N:19]([CH2:41][C:42]3[CH:47]=[CH:46][N:45]=[CH:44][CH:43]=3)[CH:18]=2)=[O:16])[CH2:10][CH2:9]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 222AmmoniaHCID 6422Trifluoroacetic acidHCID 575517434-{[6-(5-Cyclopropylcarbamoyl-2-methyl-phenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydro-isoquinoline-4-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 250205606-(5-Cyclopropylcarbamoyl-2-methyl-phenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydro-isoquinoline-4-carboxylic acid piperidin-4-ylamide

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒

実験手順

To a solution of the product of step i) (0.1 g) in dichloromethane (9 mL) was added trifluoroacetic acid (1 mL) and the mixture stirred at room temperature for 1 hour. The reaction was basified by the addition of 0.88 ammonia and washed with water. The organics were dried over magnesium sulphate, filtered and concentrated to dryness to yield the title compound as a solid (0.08 g).

後処理

  1. washwashed with water
  2. dry with materialThe organics were dried over magnesium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-b3c455767a294e62a6951e1b0663eff1
出典データセット
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08012979B2

反応ノート

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このページの内容参加物実験手順後処理出典と根拠反応ノート