1-Methylpiperazine → N-Cyclopropyl-3-fluoro-4-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-2-(4-(methylsulfonyl)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)benzamide

反応式

[CH:1]1([NH:4][C:5](=[O:38])[C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]4[C:19](=[CH:20][CH:21]=3)[C:18](=[O:22])[N:17]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([S:30]([CH3:33])(=[O:32])=[O:31])=[CH:26][CH:25]=3)[CH:16]=[C:15]4[CH:34]=O)[C:9]([CH3:36])=[C:8]([F:37])[CH:7]=2)[CH2:3][CH2:2]1.[CH3:39][N:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1>>[CH:1]1([NH:4][C:5](=[O:38])[C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]4[C:19](=[CH:20][CH:21]=3)[C:18](=[O:22])[N:17]([CH2:23][C:24]3[CH:25]=[CH:26][C:27]([S:30]([CH3:33])(=[O:31])=[O:32])=[CH:28][CH:29]=3)[CH:16]=[C:15]4[CH2:34][N:43]3[CH2:44][CH2:45][N:40]([CH3:39])[CH2:41][CH2:42]3)[C:9]([CH3:36])=[C:8]([F:37])[CH:7]=2)[CH2:2][CH2:3]1

参加物

反応物 2

HCID 531671-Methylpiperazine

HCID 57551746N-Cyclopropyl-3-fluoro-5-(4-formyl-2-(4-(methylsulfonyl)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

生成物 1

HCID 57551753N-Cyclopropyl-3-fluoro-4-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-2-(4-(methylsulfonyl)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)benzamide

実験手順

The title compound was prepared by the method of Example 59 step iv) using product of example 112 step i) and 1-methyl-piperazine.

出典と根拠

ORDレコード: ord-4917fedff6e24697a3659dd3b1a4e324
出典データセット: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08012979B2

反応ノート

読み込み中…