Borane → 2-(1-Piperazinyl)benzyl alcohol

HRID 907578ノート

反応式

HRID 907578 の反応式
S(=O)(=O)(O)O.[N:6]1([C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14](O)=[O:15])[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.B>O1CCCC1.CO>[N:6]1([C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[CH2:14][OH:15])[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1

参加物

5

反応物 2

HCID 6331BoraneHCID 673880502-Piperazin-1-yl-benzoic acid sulfuric acid salt

生成物 1

HCID 220780362-(1-Piperazinyl)benzyl alcohol

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

2-piperazin-1-yl-benzoic acid sulfuric acid salt (˜10 mmol) was suspended in 50 mL of tetrahydrofuran. Then 100 mL of 1.0 M borane in tetrahydrofuran (100 mmol) was added and the reaction was stirred at room temperature overnight with a bubbler attached to release pressure in the flask. The reaction mixture was diluted with 50 mL of methanol. The reduced product (470 mg) crystallized out of the mixture during evaporation.

後処理

  1. customThe reduced product (470 mg) crystallized out of the mixture during evaporation

出典と根拠

ORDレコード
ord-8364e2160a8e400b860f1ad26cced702
出典データセット
uspto-grants-2011_09
特許番号
US08013156B2

反応ノート

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