N-(4-bromo-2-fluorophenyl)-6-fluoro-1,3-benzothiazol-2-amine → CY477Rqr44

HRID 907755

反応式

HRID 907755 の反応式
Br[C:2]1[CH:21]=[CH:20][C:5]([C:6]([C@@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[O:7])=[CH:4][CH:3]=1.Br[C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30]2[S:31][C:32]3[CH:38]=[C:37]([F:39])[CH:36]=[CH:35][C:33]=3[N:34]=2)=[C:25]([F:40])[CH:24]=1.[F:41][C:42]1[CH:43]=[C:44]([C:63]2[CH:68]=[CH:67][C:66]([C:69]([C@@H:71]3[CH2:75][CH2:74][CH2:73][C@H:72]3[C:76]([O:78]C)=[O:77])=[O:70])=[CH:65][CH:64]=2)[CH:45]=[CH:46][C:47]=1[NH:48][C:49]1[S:50][C:51]2[CH:57]=[C:56](OC(F)(F)F)[CH:55]=[CH:54][C:52]=2[N:53]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[F:40][C:25]1[CH:24]=[C:23]([C:2]2[CH:21]=[CH:20][C:5]([C:6]([C@@H:8]3[CH2:12][CH2:11][CH2:10][C@H:9]3[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[O:7])=[CH:4][CH:3]=2)[CH:28]=[CH:27][C:26]=1[NH:29][C:30]1[S:31][C:32]2[CH:38]=[C:37]([F:39])[CH:36]=[CH:35][C:33]=2[N:34]=1.[F:41][C:42]1[CH:43]=[C:44]([C:63]2[CH:64]=[CH:65][C:66]([C:69]([C@@H:71]3[CH2:75][CH2:74][CH2:73][C@H:72]3[C:76]([OH:78])=[O:77])=[O:70])=[CH:67][CH:68]=2)[CH:45]=[CH:46][C:47]=1[NH:48][C:49]1[S:50][C:51]2[CH:57]=[C:56]([F:39])[CH:55]=[CH:54][C:52]=2[N:53]=1

参加物

7

反応物 3

HCID 7147089N-(4-bromo-2-fluorophenyl)-6-fluoro-1,3-benzothiazol-2-amineHCID 58681324tert-butyl (1R,2R)-2-(4-bromobenzoyl)-cyclopentanecarboxylateHCID 58681326methyl (1R,2R)-2-[(3'-fluoro-4'-{[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]amino}-1,1'-biphenyl-4-yl)carbonyl]cyclopentanecarboxylate

生成物 2

HCID 44464393CY477Rqr44収率 77%HCID 86594966tert-Butyl (1R,2R)-2-({3'-fluoro-4'-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylate

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

tert-Butyl (1R,2R)-2-({3′-fluoro-4′-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-1,1′-biphenyl-4-yl}carbonyl)cyclopentanecarboxylate was prepared from tert-butyl (1R,2R)-2-(4-bromobenzoyl)-cyclopentanecarboxylate and N-(4-bromo-2-fluorophenyl)-N-(6-fluoro-1,3-benzothiazol-2-yl)amine in a similar manner to that described above for methyl (1R,2R)-2-[(3′-fluoro-4′-{[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]amino}-1,1′-biphenyl-4-yl)carbonyl]cyclopentanecarboxylate. A solution of the tert-butyl ester (1.5 g, 2.81 mmol) in 2.0 mL TFA and 10 mL CH2Cl2 was stirred at rt overnight. After the solvent was removed by rotary evaporation, 50 mL EtOAc and 50 mL water were added. The organic layer was separated, washed with 50 mL water, and then dried over Na2SO4. After the solvent was removed by rotary evaporation, 5 mL EtOAc was added to the residue, followed by 5 mL hexanes. The precipitate that formed was collected by filtration to afford the desired product as a light yellow solid (1.0 g, 77%, 95.2% ee). 1H NMR (400 MHz, DMSO-d6) δ 12.20 (br s, 1H), 10.50 (bs, 1H), 8.70 (t, 1H), 7.60-8.10 (m, 8H), 7.20 (t, 1H), 4.10 (m, 1H), 3.20 (m, 1H), 2.20 (m, 1H), 2.00 (m, 1H), 1.50-1.90 (m, 4H); LC-MS m/z 479.3 (MH+), ret. time 3.64 min.

後処理

  1. customAfter the solvent was removed by rotary evaporation, 50 mL EtOAc and 50 mL water
  2. additionwere added
  3. customThe organic layer was separated
  4. washwashed with 50 mL water
  5. dry with materialdried over Na2SO4
  6. customAfter the solvent was removed by rotary evaporation, 5 mL EtOAc
  7. additionwas added to the residue
  8. customThe precipitate that formed
  9. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-8b604805b1bb4eb1b511758833a4c10f
出典データセット
uspto-grants-2011_09
特許番号
US08013166B2

関連ノート

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