Potassium Carbonate → 1-Propyl-1H-imidazole-2-carbaldehyde
反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]=[O:7].I[CH2:9][CH2:10][CH3:11].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:9]([N:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]=[O:7])[CH2:10][CH3:11]参加物
5
反応条件
- 温度
- 50 °C
実験手順
1H-imidazole-2-carbaldehyde (800 mg, 8.3 mmol), 1-iodopropane (1.7 g, 10 mmol) and potassium carbonate (1.4 g) were added in DMF (30 mL) and the mixture was heated to 50° C. overnight. Then the mixture was evaporated under reduced pressure, and extracted with ethyl acetate (100 mL×4). The combined organic layers were dried over anhydrous sodium sulfate, concentrated to give 1-propyl-1H-imidazole-2-carbaldehyde (1.1 g). LC-MS (ESI) m/z 139 (M+1)+.
後処理
- customThen the mixture was evaporated under reduced pressure
- extractionextracted with ethyl acetate (100 mL×4)
- dry with materialThe combined organic layers were dried over anhydrous sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-53d115cc72f44acbb96c8ebbcf5f2d66
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08012976B2
反応ノート
読み込み中…