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Sulfuric acid magnesium salt (1:1) → HCID 178519079、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | 1-benzyl-1H-imidazole-2-carbaldehyde | HCID 139082 | — |
| 反応物 | 4-Amino-1,3-dihydro-2-benzofuran-1-one | HCID 12284649 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 178519079 | HCID 178519079 | 100.1% |
反応手順
The mixture of 1-benzyl-1H-imidazole-2-carbaldehyde (430 mg, 1.48 mmol), 4-aminoisobenzofuran-1(3H)-one (221 mg, 1.48 mmol) and magnesium sulfate (4.3 g) in acetonitrile was heated to reflux for 48 hr. Then the mixture was filtrated off and evaporated to remove the solvent. The crude was re-crystallized from isopropanol to obtain the title compound (470 mg, 65%). LC-MS (ESI) m/z: 318 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08012976B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-a7b753ab10104293817030635d0a43c4 |
| 出典メモ | uspto-grants-2011_09 |