Sodium Methoxide → Sodium 2-cyano-3-methoxy-benzenethiolate
反応式
[CH3:1][O:2][C:3]1[C:8]2[CH:9]=[N:10][S:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.C[O-].[Na+:14]>COCCOC>[C:9]([C:8]1[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=1[S-:11])#[N:10].[Na+:14]参加物
4
反応条件
- 温度
- 80 °C
実験手順
15.5 g (93.8 mmol) 4-Methoxy-benzo[d]isothiazole were dissolved in 200 ml ethylene glycol dimethyl ether at room temperature. 10.45 g (188 mmol) sodium methoxide were added. The mixture was heated to 80° C. for 8 h and stirring was continued at room temperature for 16 h. The mixture was divided and one quarter of the mixture was used in the subsequent synthesis without further purification.
後処理
- customone quarter of the mixture was used in the subsequent synthesis without further purification
出典と根拠
- ORDレコード
- ord-1751b7d6fee3490f99a5993e362afb94
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08017554B2
反応ノート
読み込み中…