2-Chloro-5-(2-oxo-propyl)-benzenesulfonamide → 5-(1-Bromo-2-oxo-propyl)-2-chloro-benzenesulfonamide
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[S:12]([NH2:15])(=[O:14])=[O:13].C1C=C[NH+]=CC=1.[Br:22][Br-]Br>C1COCC1>[Br:22][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([S:12]([NH2:15])(=[O:14])=[O:13])[CH:4]=1)[C:9](=[O:11])[CH3:10]参加物
3
実験手順
A stirred solution of 2-chloro-5-(2-oxo-propyl)-benzenesulfonamide (33a) (1.4 g, 5.7 mmol) in dry THF (100 ml) at room temperature is treated with polymer supported pyridine hydrobromide perbromide (2.9 g, 5.7 mmol) and left to stir overnight. The reaction mixture is then filtered and the solvent removed in vacuo. The residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane to give the titled compound.
後処理
- waitleft
- filtrationThe reaction mixture is then filtered
- customthe solvent removed in vacuo
- customThe residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane
出典と根拠
- ORDレコード
- ord-fa16fbc243584ccc954fa7c37f7cfb21
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08017608B2
反応ノート
読み込み中…