Sodium Acetate → 3,5-Difluorotoluene

HRID 908241ノート

反応式

HRID 908241 の反応式
Br[CH2:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[C:5]([F:10])[CH:4]=1.C([O-])(=O)C.[Na+]>CCOCC.[Pd]>[F:9][C:7]1[CH:8]=[C:3]([CH3:2])[CH:4]=[C:5]([F:10])[CH:6]=1

参加物

5

反応物 2

HCID 517045Sodium AcetateHCID 5188963,5-Difluorobenzyl bromide

生成物 1

HCID 27783293,5-Difluorotoluene

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 1-(bromomethyl)-3,5-difluorobenzene (50 g, 0.24 mol), 10% Pd/C (3 g) and sodium acetate (140 g, 1.7 mol) in anhydrous ether (250 mL) was stirred under hydrogen at atmospheric pressure for 24 hr. The mixture was filtered and the filtrate was dried over anhydrous Na2SO4, filtered and used directly in the next step. 1H-NMR (500 MHz, CDCl3): δ 6.56 (d, 2H, J=6.0 Hz), 6.47 (t, 1H, J=9.0 Hz), 2.22 (s, 3H).

後処理

  1. filtrationThe mixture was filtered
  2. dry with materialthe filtrate was dried over anhydrous Na2SO4
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-142d52581a6f4ee5a4b9467cfba32377
出典データセット
uspto-grants-2011_09
特許番号
US08017605B2

反応ノート

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