Triethylamine → HCID 67386992、化合物

HRID 908321ノート

反応式

HRID 908321 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[C:23](=[O:24])[CH2:22][CH:21]([C:25]([O:27]C)=[O:26])[CH2:20]3)=[CH:15][CH:14]=2)=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2.[OH-].[Na+].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(CC)CC>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:13]2[CH:14]=[CH:15][C:16]([N:19]3[C:23](=[O:24])[CH2:22][CH:21]([C:25]([OH:27])=[O:26])[CH2:20]3)=[CH:17][CH:18]=2)=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2

参加物

6

反応物 4

HCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 58828844HCID 58828844、化合物

生成物 1

HCID 67386992HCID 67386992、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
80 °C

実験手順

A mixture of methyl 1-(4-(8-methoxyisoquinolin-5-yl)phenyl)-5-oxopyrrolidine-3-carboxylate (220 mg, 0.58 mmol) in dioxane (2 mL) was treated with NaOH (1N, 1 mL). The mixture was heated to 80° C. for 17 h and the solvents were evaporated to dryness. MS (ESI pos. ion) m/z: 363 (M+H). The acid was dissolved in DMF (2 mL) and was treated with HBTU (450 mg, 1.25 mmol) and Et3N (1 mL). The solution was divided into two equal portions and was used directly.

後処理

  1. customthe solvents were evaporated to dryness
  2. dissolutionThe acid was dissolved in DMF (2 mL)

出典と根拠

ORDレコード
ord-991abe7f7c2a4acdaad03154b2d636fb
出典データセット
uspto-grants-2011_09
特許番号
US08017601B2

反応ノート

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