Chloride → 6-(Isoquinolin-5-yl)naphthalene-1-carboxamide

HRID 908327ノート

反応式

HRID 908327 の反応式
[CH:1]1[C:10]2[C:5](=[C:6]([C:11]3[CH:12]=[C:13]4[C:18](=[CH:19][CH:20]=3)[C:17]([C:21](O)=[O:22])=[CH:16][CH:15]=[CH:14]4)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[Cl-].C[N:26](C=O)C>C(Cl)Cl>[CH:1]1[C:10]2[C:5](=[C:6]([C:11]3[CH:12]=[C:13]4[C:18](=[CH:19][CH:20]=3)[C:17]([C:21]([NH2:26])=[O:22])=[CH:16][CH:15]=[CH:14]4)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

参加物

5

反応物 3

HCID 312ChlorideHCID 6228DimethylformamideHCID 58828852HCID 58828852、化合物

生成物 1

HCID 588288596-(Isoquinolin-5-yl)naphthalene-1-carboxamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

6-(isoquinolin-5-yl)-1-naphthoic acid (0.86 mg, 0.29 mmol) was suspended in CH2Cl2 (2 mL) and oxallyl chloride (0.038 mL, 0.4 mmol) was added followed by a drop of DMF. Mixture was stirred at room temperature for 3 h and solvent was evaporated and residue dried under vacuum. The crude acid chloride was dissolved in a solution of NH3 in dioxane and was stirred at room temperature. Solvent was evaporated, a solution of aqueous NaHCO3 was added and the mixture was extracted with CH2Cl2 and then with ethyl acetate. Residue was purified by prep plate (5% MeOH/CH2Cl2) to give the title compound as a solid. MS (ESI pos. ion) m/z: 299. (M+H). Calc'd Exact Mass for C20H14N2O: 298.

後処理

  1. customsolvent was evaporated
  2. customresidue dried under vacuum
  3. dissolutionThe crude acid chloride was dissolved in a solution of NH3 in dioxane
  4. stirringwas stirred at room temperature
  5. customSolvent was evaporated
  6. additiona solution of aqueous NaHCO3 was added
  7. extractionthe mixture was extracted with CH2Cl2
  8. customResidue was purified by prep plate (5% MeOH/CH2Cl2)

出典と根拠

ORDレコード
ord-bcc1d8c98b9a4a029c322892a42e191b
出典データセット
uspto-grants-2011_09
特許番号
US08017601B2

反応ノート

読み込み中…