HCID 67392848、化合物 → HCID 67393545、化合物

反応式

[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[S:11][C:12]4[C:18]([N+:19]([O-])=O)=[C:17]([O:22][CH3:23])[CH:16]=[CH:15][C:13]=4[N:14]=3)=[CH:9][C:4]=2[O:3][CH2:2]1.[H][H]>CO.[Pd]>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[S:11][C:12]4[C:18]([NH2:19])=[C:17]([O:22][CH3:23])[CH:16]=[CH:15][C:13]=4[N:14]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

参加物

実験手順

0.96 g (2.9 mmol) of 2-(1,3-benzodioxol-5-yl)-6-methoxy-7-nitro-1,3-benzothiazole is suspended in 100 ml of methanol. 96 mg (10%) of palladium on carbon is added to the reaction mixture which is maintained under stirring under 2.5 bars of hydrogen for 18 hours. The catalyst is filtered out, then the solvents are evaporated off under reduced pressure. 0.45 g (yield=52%) of 2-(1,3-benzodioxol-5-yl)-6-methoxy-1,3-benzothiazol-7-amine is obtained and used in the following stage without other purification.