Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide hydrochloride

HRID 908931ノート

反応式

HRID 908931 の反応式
[CH3:1][N:2]([CH3:26])[C:3]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:27][Si](C)(C)C>CC(CC)=O>[ClH:27].[CH3:26][N:2]([CH3:1])[C:3]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:4][CH2:5][C:6](=[CH:9][C:10]([NH:12][C:13]2[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=2)=[O:11])[CH2:7][CH2:8]1

参加物

4

反応物 2

HCID 6397ChlorotrimethylsilaneHCID 115383312-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide

生成物 1

HCID 115383302-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide hydrochloride収率 52%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluoro-phenyl)acetamide (266 mg, 0.755 mmol) was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.139 ml, 1.1 mmol) was added. After 2.5 h the hydrochloride was isolated as a colourless solid in a yield of 52% (152 mg).

出典と根拠

ORDレコード
ord-78bb9bef1af44779ac8b2aa8182f185e
出典データセット
uspto-grants-2011_09
特許番号
US08017630B2

反応ノート

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