Chlorotrimethylsilane → HCID 11705177、化合物
反応式
[CH3:1][N:2]([CH3:31])[C:3]1([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][CH:16]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:32][Si](C)(C)C>CC(CC)=O>[ClH:32].[CH3:31][N:2]([CH3:1])[C:3]1([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][CH:16]=2)=[O:11])[CH2:5][CH2:4]1参加物
4
実験手順
2-[4-Dimethylamino-4-(4-fluorophenyl)cyclo hexylidene)-N-[2-(1H-indol-3-yl)ethyl]acetamide (871 mg, 2.08 mmol) was dissolved in ethyl methyl ketone (35 ml), and chlorotrimethylsilane (0.39 ml, 3.11 mmol) was added. After 1.5 h the hydrochloride was isolated as a beige-coloured solid with an m.p. of 217-221° C. in a yield of 85% (810 mg).