Chlorotrimethylsilane → HCID 11604570、化合物

HRID 908951ノート

反応式

HRID 908951 の反応式
[CH3:1][N:2]([CH3:30])[C:3]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][CH:16]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:31][Si](C)(C)C>CC(CC)=O>[ClH:31].[CH3:30][N:2]([CH3:1])[C:3]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)[CH2:4][CH2:5][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][CH:16]=2)=[O:11])[CH2:7][CH2:8]1

参加物

4

反応物 2

HCID 6397ChlorotrimethylsilaneHCID 11604571HCID 11604571、化合物

生成物 1

HCID 11604570HCID 11604570、化合物収率 89%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

2-(4-Dimethylamino-4-pyridin-2-ylcyclohexylidene)-N-[2-(1H-indol-3-yl)ethyl]acetamide (210 mg, 0.52 mmol) was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.19 ml, 1.5 mmol) was added. After 1.5 h the hydrochloride was isolated as a beige-coloured solid with an m.p. of 147-150° C. in a yield of 89% (203 mg).

出典と根拠

ORDレコード
ord-11ed6729b88f4fc28555802e1b1a7c98
出典データセット
uspto-grants-2011_09
特許番号
US08017630B2

反応ノート

読み込み中…