Chlorotrimethylsilane → 2-[4-Dimethylamino-4-(3-fluorophenyl)cyclohexylidene]-N-[2-(1H-indol-3-yl)-1-methylethyl]acetamide hydrochloride
反応式
C[Si](C)(C)[Cl:3].[CH3:6][N:7]([CH3:37])[C:8]1([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[CH:31]=2)[CH2:13][CH2:12][C:11](=[CH:14][C:15]([NH:17][CH:18]([CH3:29])[CH2:19][C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][CH:21]=2)=[O:16])[CH2:10][CH2:9]1>CC(CC)=O>[ClH:3].[CH3:37][N:7]([CH3:6])[C:8]1([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[CH:31]=2)[CH2:13][CH2:12][C:11](=[CH:14][C:15]([NH:17][CH:18]([CH3:29])[CH2:19][C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][CH:21]=2)=[O:16])[CH2:10][CH2:9]1参加物
4
実験手順
Trimethylchlorosilane (0.109 ml, 0.86 mmol) was added to a solution of the more polar diastereoisomer of 2-[4-dimethylamino-4-(3-fluorophenyl)cyclohexylidene]-N-[2-(1H-indol-3-yl)-1-methylethyl]acetamide (249 mg, 0.57 mmol) in ethyl methyl ketone (10 ml) and the mixture was stirred at RT for 1.5 h. The hydrochloride which had precipitated out was filtered off with suction and isolated as a colourless solid with an m.p. of 171-174° C. in a yield of 81% (218 mg) (Example 27).