Hydrochloric Acid → 2-(4-Ethylbenzyl)phenol
反応式
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH:15]([C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[CH:19][CH:18]=1)O)C1C=CC=CC=1.Cl>[Pd].CO>[CH2:23]([C:20]1[CH:21]=[CH:22][C:17]([CH2:15][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[OH:8])=[CH:18][CH:19]=1)[CH3:24]参加物
5
実験手順
Then a mixture of (2-benzyloxyphenyl)(4-ethylphenyl)methanol (78.5 g), 10% palladium activated carbon (5.2 g), concentrated hydrochloric acid (10.4 mL) and methanol (850 mL) was stirred under hydrogen atmosphere at room temperature for 24 hours. After filtering off the insolubles, the filtrate was evaporated under reduced pressure and then, the residue was distilled under reduced pressure to obtain the title compound (56.8 g) as a colorless oil.
後処理
- filtrationAfter filtering off the insolubles
- customthe filtrate was evaporated under reduced pressure
- distillationthe residue was distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-40716aebeb5344dda2449656d5a06df7
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08017792B2
反応ノート
読み込み中…