Water → 5-[4-(6-Bromo-1,3-benzothiazol-2-yl)phenyl]-1,3-oxazole

HRID 910233

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[SH:9].[O:10]1[C:14]([C:15]2[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=2)=[CH:13][N:12]=[CH:11]1.O>CS(C)=O>[Br:8][C:5]1[CH:6]=[CH:7][C:2]2[N:1]=[C:19]([C:18]3[CH:17]=[CH:16][C:15]([C:14]4[O:10][CH:11]=[N:12][CH:13]=4)=[CH:22][CH:21]=3)[S:9][C:3]=2[CH:4]=1

参加物

反応条件

温度: 160 °C

実験手順

2 Amino-5-bromobenzenethiol (102 mg) and 4-(1,3-oxazol-5-yl)benzaldehyde (87 mg) were dissolved in dimethylsulfoxide (1 mL), followed by stirring at 160° C. for 10 minutes. Water (10 mL) was added to the reaction mixture. The precipitated matter was recovered through filtration, and washed with methanol, to thereby yield the title compound (105 mg).

後処理

filtrationThe precipitated matter was recovered through filtration
washwashed with methanol

出典と根拠

ORDレコード: ord-0e754375d48d4d6aa7a3d6b803037183
出典データセット: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08022075B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

反応条件

実験手順

後処理

出典と根拠

関連ノート