Hydrochloric Acid → 4-(1-Methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid

HRID 910608ノート

反応式

HRID 910608 の反応式
[OH-].[Na+].[CH3:3][N:4]1[CH:9]=[CH:8][C:7](=[O:10])[C:6]([C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17]C)=[O:16])=[CH:13][CH:12]=2)=[CH:5]1.Cl>CCO>[CH3:3][N:4]1[CH:9]=[CH:8][C:7](=[O:10])[C:6]([C:11]2[CH:20]=[CH:19][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=2)=[CH:5]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57583987Methyl 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoate

生成物 1

HCID 575840694-(1-Methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid収率 84.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1 M NaOH (1.42 ml) was added to an EtOH suspension (3 ml) of methyl 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoate (115 mg), followed by stirring at room temperature for 8 hours. 1 M HCl (1.42 ml) was added to the reaction solution, followed by concentration under reduced pressure. Water (20 ml) was added to the residue, followed by stirring for 20 minutes. The precipitate formed was collected by filtration and dried under reduced pressure at 60° C. to obtain 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid (92 mg).

後処理

  1. concentrationfollowed by concentration under reduced pressure
  2. additionWater (20 ml) was added to the residue
  3. stirringby stirring for 20 minutes
  4. customThe precipitate formed
  5. filtrationwas collected by filtration
  6. customdried under reduced pressure at 60° C.

出典と根拠

ORDレコード
ord-93825d8b1fd04ca68dd31dbe8ae0f235
出典データセット
uspto-grants-2011_09
特許番号
US08022208B2

反応ノート

読み込み中…