1-Methylpiperazine → 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

HRID 910681ノート

反応式

HRID 910681 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>CCO>[Cl:1][C:2]1[N:7]=[C:6]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)[CH:5]=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 531671-MethylpiperazineHCID 775312,4-Dichloropyrimidine

生成物 1

HCID 17142252-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2,4-dichloropyrimidine (740 mg, 5 mmol) in EtOH (15 mL) was slowly added 1-methylpiperazine (550 mg, 5.5 mmol). The resulting mixture was stirred at room temperature overnight, then was concentrated, diluted with water, and extracted with CH2Cl2. The organic layer was dried and concentrated to yield 2-chloro-4-(4-methyl-piperazin-1-yl)-pyrimidine.

後処理

  1. concentrationwas concentrated
  2. additiondiluted with water
  3. extractionextracted with CH2Cl2
  4. customThe organic layer was dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-73e60837939b41ff82c9ae5a0b6276c6
出典データセット
uspto-grants-2011_09
特許番号
US08022209B2

反応ノート

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