1-Methylpiperazine → 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

HRID 910690ノート

反応式

HRID 910690 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>C(O)C>[Cl:1][C:2]1[N:7]=[C:6]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)[CH:5]=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 531671-MethylpiperazineHCID 775312,4-Dichloropyrimidine

生成物 1

HCID 17142252-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2,4-dichloropyrimidine (447 mg, 3 mmol) in ethanol (10 mL) was added 1-methylpyperazine (360 mg, 3.6 mmol). The resulting mixture was stirred at room temperature overnight. The resulting white solid was collected by filtration and washed with ethanol, Na2CO3 solution and water and ethanol.

後処理

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed with ethanol, Na2CO3 solution and water and ethanol

出典と根拠

ORDレコード
ord-5aa3ce636099429b85a813584cc09145
出典データセット
uspto-grants-2011_09
特許番号
US08022209B2

反応ノート

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