Sodium hydrosulfide → 2-Chloro-4-(ethylsulfonyl)benzenethiol
反応式
[SH-:1].[Na+].[CH2:3]([S:5]([C:8]1[CH:13]=[CH:12][C:11](F)=[C:10]([Cl:15])[CH:9]=1)(=[O:7])=[O:6])[CH3:4]>CN(C=O)C.[OH-].[Na+]>[Cl:15][C:10]1[CH:9]=[C:8]([S:5]([CH2:3][CH3:4])(=[O:7])=[O:6])[CH:13]=[CH:12][C:11]=1[SH:1]参加物
5
実験手順
Sodium hydrosulphide (0.252 g) was added to the product from example 4 step (i) (11.0 g) in dry DMF (10 ml) and stirred at RT for 2 h. The mixture was diluted with 2M sodium hydroxide solution and extracted with diethylether. The aqueous layer was acidified with 2M hydrochloric acid, extracted with ethyl acetate, dried and evaporated under reduced pressure, crude yield 1.60 g.
後処理
- extractionextracted with diethylether
- extractionextracted with ethyl acetate
- customdried
- customevaporated under reduced pressure, crude yield 1.60 g
出典と根拠
- ORDレコード
- ord-2c5ad7ee73c7461dbae0cf95dc3459cd
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022248B2
反応ノート
読み込み中…