Hydrogen Bromide → 4-Chloro-2-hydroxyphenylacetic acid
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[C:4]([O:12]C)[CH:3]=1.Br>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[C:4]([OH:12])[CH:3]=1参加物
4
実験手順
4-chloro-2-methoxy-benzeneacetic acid (1.4 g), HBr (25 ml), acetic acid (5 ml) were refluxed for 48 h then evaporated under reduced pressure. The residue was azeotroped with toluene and triturated with diethyl ether and isohexane. Yield 0.56 g.
後処理
- customthen evaporated under reduced pressure
- customThe residue was azeotroped with toluene
- customtriturated with diethyl ether and isohexane
出典と根拠
- ORDレコード
- ord-aec44375af674c33840c44931fe1fa8a
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022248B2
反応ノート
読み込み中…