Potassium Phosphate, Tribasic → N-(4-(2,3-dichlorophenylthio)pyridin-2-yl)-4-methylthiazol-2-amine

HRID 910986ノート

反応式

HRID 910986 の反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH2:7])[S:5][CH:6]=1.Cl[C:9]1[CH:14]=[C:13]([S:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:17]=2[Cl:23])[CH:12]=[CH:11][N:10]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(P(C2C=CC=CC=2)C2C3OC4C(=CC=CC=4P(C4C=CC=CC=4)C4C=CC=CC=4)C(C)(C)C=3C=CC=2)C=CC=CC=1>[Cl:23][C:17]1[C:18]([Cl:22])=[CH:19][CH:20]=[CH:21][C:16]=1[S:15][C:13]1[CH:12]=[CH:11][N:10]=[C:9]([NH:7][C:4]2[S:5][CH:6]=[C:2]([CH3:1])[N:3]=2)[CH:14]=1

参加物

6

反応物 3

HCID 62657Potassium Phosphate, TribasicHCID 741432-Amino-4-methylthiazoleHCID 866347332-Chloro-4-(2,3-dichlorophenylthio)pyridine

生成物 1

HCID 24826587N-(4-(2,3-dichlorophenylthio)pyridin-2-yl)-4-methylthiazol-2-amine収率 76%

試薬・触媒・溶媒 2

HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)触媒HCID 9811564Bis(dibenzylideneacetone)palladium触媒

実験手順

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.196 g, 1.72 mmol), 2-chloro-4-(2,3-dichlorophenylthio)pyridine (0.500 g, 1.72 mmol), potassium phosphate (0.402 g, 1.89 mmol), Pd2(dba)3 (0.079 g, 0.086 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.050 g, 0.086 mmol) were reacted to provide N-(4-(2,3-dichlorophenylthio)pyridin-2-yl)-4-methylthiazol-2-amine (0.480 g, 76% yield). 1H NMR (d6-DMSO) δ 11.10 (s, 1H), 8.15 (d, 1H), 7.82 (d, 1H), 7.66 (d, 1H), 7.49 (t, 1H), 6.71 (s, 1H), 6.69 (d, 1H), 6.54 (s, 1H), 2.20 (s, 3H).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-70ae68f2145442c5bae5787ce0764bae
出典データセット
uspto-grants-2011_09
特許番号
US08022222B2

反応ノート

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