Hydrochloric Acid → 1-(6-Fluoropyridin-2-yl)methanamine--hydrogen chloride (1/2)

HRID 911315ノート

反応式

HRID 911315 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[N:4]=1)#[N:2].[ClH:10]>C(O)C.[Pd]>[ClH:10].[ClH:10].[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[N:4]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 142963696-Fluoropyridine-2-carbonitrile

生成物 1

HCID 513420701-(6-Fluoropyridin-2-yl)methanamine--hydrogen chloride (1/2)収率 73%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Dissolve 2-cyano-6-fluoropyridine (300 mg, 2.46 mmol) in absolute ethanol (12 mL). Add 10% Pd/C (93 mg) and concentrated HCl (0.614 mL, 7.37 mmol). Hydrogenate at 40 psi overnight. Filter through Celite® and concentrate to give the title compound as a solid (356 mg, 73%). MS (ES+) m/z: 127 (M+H)+.

後処理

  1. customat 40 psi overnight
  2. filtrationFilter through Celite®
  3. concentrationconcentrate

出典と根拠

ORDレコード
ord-f08b407447a94c8dab46589a9cf43047
出典データセット
uspto-grants-2011_09
特許番号
US08022062B2

反応ノート

読み込み中…