戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 911528作成日：2026年10月26日

1-[4-(Bromomethyl)phenyl]ethan-1-one → 6-(4-acetylbenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine

https://huagongshe.com/reaction/911528

反応式

関与物質

役割名称HCID仕込み量
反応物1-[4-(Bromomethyl)phenyl]ethan-1-oneHCID 583785—
反応物3-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 57655979—
生成物6-(4-acetylbenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 57656189—

反応手順

Use a method similar to the Example 380, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 4-acetylbenzyl bromide to give, after chromatography eluting with hexane/EtOAc (15:1), the desired intermediate as a white solid. MS (APCI+) m/z 346 (M+H−Boc)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08022062B2
出典データセットuspto-grants-2011_09
ORD IDord-a242c8b05f6d4b9497cdfd6d4ef43606
出典メモuspto-grants-2011_09